Answer
1) Inactivate thrombin and factor Xa through antithrombin-dependent mechanism.
2) Indication for the drug includes
- Pulmonary embolism and venous thrombosis
- treatment for acute coronary syndrome
- Prophylaxis for venous thromboembolism
3) Monitoring of APTT
4) Drug side effect
- bleeding
- heparin induced thrombocytopenia
5) Protamine sulfate