Answer
1) Symptomatic anaemia secondary to Beta Thalassemia Major
2) Autosomal recessive causing mutation of HBB gene on chromosome 11
3) Hepatosplenomegally due to increase in hemolysis and extra-medullary hematopoiesis in response to anemia.
4) Packed cell
5) Long term complication of blood transfusion
a) Iron overload
b) Transmission of infectious disease like HIV, Hepatitis, CMV and syphilis.
c) Red cell alloimmunization